At the same time, an assortment of tweaks will be made to ensure that the mission goes smoothly:
[#1] Greatly increased chance of receiving your job-specific weapon!
Previously, only the nastiest adversaries in the darkest, dankest reaches of Nyzul Isle (Level 100) would part with the job-specific weapons adventurers seek. Now, there is a possibility that foes on other floors will drop these weapons as well, while defeating the denizens of Level 100 will guarantee you two job-specific weapons: one randomly selected, and one matching the job of the player who operated the Rune of Transfer (the latter regardless of whether or not that player also possesses the Runic Key.)

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[#2] Progress saved to Runic Disc to be retained!
Previously, your recorded data would be reset upon completing Level 100 of the mission, reducing your Runic Disc to a rather expensive paperweight until such time as you begin the mission anew. No longer, however, as your progress data will now remain intact even after cleansing the Isle of its most deadly inhabitants, allowing you to return to the most challenging levels for another chance at the weapon you seek!
Read More Here.
Resource: Curse